The 32-year-old Anderson triumphed 7-6 (8/6), 6-7 (5/7), 6-7 (9/11), 6-4, 26-24 after six hours and 36 minutes on Centre Court.
In a first-round Wimbledon match in 2010, Isner battled Nicolas Mahut in a fifth set that dragged out three days, finally ending in Isner's favor, 70-68.
It was also the second longest match at a Slam, beating the six hours and 33 minutes which Fabrice Santoro spent seeing off Arnaud Clement in the 2004 French Open.
When asked after his victory about Anderson, Djokovic said: "Well, I mean, considering he's playing only his second grand slam final, obviously he has a lot more to gain". I really feel for him. Anderson is going to have to play the match of his life on Centre Court.
"I apologise if I´m not more excited right now". So if I would have won in straight sets, then it could have been all right, you know, because I would have had a great first set, and second set was whatever it was.
Of the 22 sets they've had available to play in their matches, they've used 17 of them, or 77%, making them one of the more likely pairings in the men's game to go the distance.
"It's hard to pick the words, I'm just going through things, the flashbacks and everything I've been through to get here, to get to finals, to win against the best player in the world", he told BBC Sport.
After splitting the first two sets, Djokovic and Nadal played to a tiebreaker in the third set.
Trump sees Putin meeting as easiest of tour The alliance says that 15 members, or just over half, will meet the benchmark by that year, based on current trends. Trump said Tuesday he "can't say right now" if Putin is a friend or foe, but called him a "competitor".
19 injured, 1 dead in South Africa plane crash Civil Aviation Authority investigators were at the scene and started the process of determining the cause of the accident. The plane was supposed to leave South Africa around Thursday, according to Dutch news agency ANP.
With the time approaching 10pm, that made it highly unlikely there would be a victor yesterday, and both players knew how important that third set was likely to be. Anderson won the toss and will serve first. But there were, in fact, several breaks of serve.
All the doomsayers against the case for Anderson winning will be putting plenty of stock on Nadal's annihilation of him in last year's US Open final. Anderson fell to his backside trying to return an Isner serve, but got to his feet with his racket in his off hand.
Another hold for 3-1.
In the 50th game, Isner took down the opening point before Anderson captured the next four - including two on aces.
Isner said that being part of yet another record-breaking match did not help ease his pain. Nadal and Djokovic regularly - and spectacularly - ran down shots to force long rallies, drawing gasps and cheers from the appreciative crowd.
Novak Djokovic was understandably emotional as he gave a post-match interview immediately after booking his place in Sunday's final.
"I'm in the finals of Wimbledon".
Djokovic, meanwhile, is seeking a fifth final at the All England Club and 22nd at the Slams.
The 2018 final is Anderson's second career grand slam final after making it to the US Open final past year before losing in straight sets to Rafael Nadal.
"We restored some pride back into the shirt, which was an important thing for us to do". "The young team have emerged as heroes". The British Retail Consortium said: "Beer, barbecues and big TVs have lifted sales".
The deal between Disney and Fox is far from finalized as the latter company's shareholders still have to vote on the acquisition. Comcast said its cash offer has been recommended by Sky's independent committee of directors.
Tintin and Asterix have always been rivals in the world of the comic strips for both are popular for their entertainment and art. FIFA boss Gianni Infantino had invited the boys' Wild Boars football team to Sunday's World Cup final last week.
Those projectiles caused thousands of Israelis to flee to bomb shelters from their homes, according to the Israel Defense Forces. The majority of those killed were involved in protests and clashes but others were seeking to breach or damage the border fence.
The Okayama prefecture said three people had died, six others were missing and seven were injured, while almost 500 were flooded. At least 60 people have died in Japan as the country is battered by the worst rains and flooding in the country's history.
Israel has warned Iran, which is allied with the Syrian government, against building up a military presence on its doorstep. On Sunday, Syria accused Israel of attacking an air force base near Homs that was known to be housing Iranian forces.
ICE has three family detention centres with room for about 3000 people in all, and the places are already at or near capacity. Sabraw showed little appetite for giving more time to the government unless it could show good reasons in specific cases.
The resignation comes two days after the whole of the cabinet met at Chequers to agree Britain's negotiating position. Ian Lavery, chair of the Labour Party, said: "This is absolute chaos and Theresa May has no authority left".
Officials say they are in good health but will not be allowed close contact with their relatives because of the risk of infection. The first four rescued boys have been placed in a ward set aside specifically for the cave rescue, a source at the hospital said.
A 2016 study published by The Lancet says breastfeeding could save the lives of 823,000 children and 20,000 mothers each year. The report said the U.S. delegation was also unsuccessful at defeating a different measure on access to medicines.
Spartak Moscow winger Alexander Samedov also confirmed he is retiring from global football after Russia's defeat. Pope consoles Brazil fans * Goal-fest?
'One of the Best on the Planet'
It's been 20 years since Croatia not only burst onto the World Cup scene, but also since they advanced beyond the group stages. They are offensive in the midfield with [Ivan] Rakitic, [Marcelo] Brozovic, [Luka] Modric , so somebody needs to fix all that.
UK's Theresa May: Trump told me to 'sue the EU' over Brexit
While there was a small pro-Trump rally that took place in London on Saturday, that was after his interview with the Daily Mail . She added: "David Davis was discussing with Michel Barnier". "I think she found it maybe too brutal", said the president .
Belgium 0-0 England
Third place for England would have been the nation's second-best performance at a World Cup, and the best on foreign soil. Belgium v/s England Tamil, Telugu, Malayalam and Bengali commentary will be on Sony ESPN and Sony ESPN HD.
West Ham Confirm The Signing Of Jack Wilshere
Wilshere had been hampered by injuries in recent years and spent the 2016-17 season on loan at Bournemouth. West Ham have confirmed the signing of Jack Wilshere on a three-year contract.
Deschamps to write a new chapter in football history
Luckily, the French players escaped with no more than just having to catch their breath after the extended celebrations. And it came from the unlikeliest of sources - Paris Saint-Germain defender with Congolese roots Presnel Kimpembe.
Apple rumoured to be updating at last
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UK PM May seeks unity amid chaos over Brexit plans
Former leader Michael Howard said a bid to oust Mrs May would be "extremely foolish and extremely ill-advised". He said: "Now that the secretary of state has resigned , clearly there will be more scrutiny on the deal".
Delays in clearing US goods as duties loom, China bouncing back
The trade dispute between the United States and China escalated on Friday, but Wall Street focused on a solid jobs report instead. Importers of American retail goods hit by higher Chinese duties were reluctant to pass the costs on to consumers for now.